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  • ItemOpen Access
    (Université de M'sila, 2020) Khezzani, Bachir
    The main objective of this paper El-Oued province by analyzing a series of statistical data. The results show that 37.9% of the teste danimalshad a positive result. The highest further more, the high incidence rate has been reported in cattle Females are more exposed to brucell incidence characterized by a strong fluctuation with an upward trend. In addition, the highest incidence rate was reported in the spring at 2.74 per 100,000 authorities are making enormous efforts to limit in the study area. This situation requires a series of urgent and specific therapeutic measures.
  • ItemOpen Access
    Antihyperglycemic and antidiabetic effects of Ethyl (S)-2-(1-cyclohexylsulfamide carbamoyloxy) propanoate in streptozotocin-induced diabetic Wistar rats
    (Université de M'sila, 2016-03) Yassine, Réggami; Hajira, Berredjem; Hadjer, Cheloufi; Malika, Berredjem; Noureddine, Bouzerna
    In this study, we examined the antihyperglycemic and antidiabetic effects of a novel synthesized molecule, the Ethyl (S)-2-(1-cyclohexylsulfamide carbamoyloxy) propanoate (ESP1b), in streptozotocin (STZ)-induced diabetic Wistar rats. Experimental diabetes mellitus was produced by a single intraperitoneal injection of STZ (55 mg/kg b.w.). Seven day post-injection, animals have received ESP1b orally at the doses of 5, 10 and 20 mg/kg b.w. daily for 28 days. This resulted in a clear decline, in a dose dependent manner, of blood glucose levels during the oral glucose tolerance test (OGTT) and the four weeks of treatment period. ESP1b at 20 mg/kg b.w. has alleviated body weight loss, improved plasma insulin concentration and at the same time markedly decreased the values of glycosylated hemoglobin, lipoproteins and atherogenic ratios. Additionally, ESP1b notably restored renal as well as hepatic functions tests. Histopathological examinations of pancreatic tissue also confirmed the previous biochemical findings. Considering the obtained results, it may be concluded that ESP1b possess a potent antihyperglycemic activity in STZ-diabetic rats possibly related to an insulin-secretagogue effect, which may be responsible for the moderate decrease in blood glucose concentration observed in normal rats administrated with this tested compound.
  • ItemOpen Access
    Essential Oil from Aerial Parts of Wild Algerian Rosemary: Screening of Chemical Composition, Antimicrobial and Antioxidant Activities
    (Université de M'sila, 2019) Noui, Hendel
    Essential oils from the aerial parts of 15 samples of Algerian Rosmarinus officinalis L. were analysed by gas chromatography (GC) and Gas chromatography/mass spectroscopy. Thirty eight components have been characterized; among the monoterpene hydrocarbons α-pinene, camphene and limonene were individuated as the main components; camphor, 1,8-cineole and borneol were the principal oxygenated compounds, caryophyllene, α-bisabolol and partly humulene were the most represented sesquiterpenes. The scavenging activity of the oils was determined by the DPPH model system. The SC50 (Scavenging Concentration) values were in the range 120.4-326.1 μL/mL, representing a moderate antioxidant effectiveness. Essential oils were evaluated for their antimicrobial activity against Escherichia coli and Staphylococcus aureus; as well as against ten fungal strains belonging to Aspergillus, Alternaria, Candida, Fusarium, Penicillium and Saccharomyces genera. The results showed a moderate antimicrobial activity. The Algerian rosemary essential oils could be promising sources of biologically active compounds if they receive further studies on their biological properties.