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Item Open Access Activité antibactérienne de l'huile essentielle de clou de girofle sur la bactérie responsable des caries dentaires(2024-06-12) SEDDIKI, ISSAM. SLIMANI, CHADA LOUBNA. MOHAMED SEGHIR, ZEYNEB. SLINI, CHAIMA.Syzygium aromaticum est une espèce de plante à fleurs de la famille des Myrtaceae et du genre Syzygium, principalement utilisée pour ses propriétés thérapeutiques en santé bucco-dentaire. Notre étude vise à évaluer l'impact de l'huile essentielle de clou de girofle extraite de cette plante sur la bactérie responsable des caries dentaires. L'huile essentielle est extraite par hydro-distillation, et la bactérie est prélevée chez un dentiste à Bou-Saâda, puis identifiée et isolée dans notre laboratoire, la méthode de diffusion sur disque est ensuite utilisée pour évaluer l'activité antibactérienne. Le rendement de l'huile essentielle était de 6,08 %, l’activité antibactérienne a été déterminée sur une souche bactérienne de Streptococcus mutans (Gram+), les diamètres d'inhibition (zone d'inhibition) variaient entre 3 mm et 15 mm, la concentration minimale inhibitrice (CMI) pour S.mutans est de 0.19. A partir de ces résultats, on peut constater que l’huile essentielle de clou de girofle (Syzygium aromaticum) exerce un pouvoir antibactérien in vitro sur la souche bactérienne étudiée et il est possible qu’elle ait une meilleure action in vivo sur l’incidence de la diminution de la formation de biofilm des caries dentaires.Item Open Access AN OVERVIEW OF ANIMAL BRUCELLOSIS IN THE PROVINCE OF EL oued (Algerien sahara)(Université de M'sila, 2020) Khezzani, BachirThe main objective of this paper El-Oued province by analyzing a series of statistical data. The results show that 37.9% of the teste danimalshad a positive result. The highest further more, the high incidence rate has been reported in cattle Females are more exposed to brucell incidence characterized by a strong fluctuation with an upward trend. In addition, the highest incidence rate was reported in the spring at 2.74 per 100,000 authorities are making enormous efforts to limit in the study area. This situation requires a series of urgent and specific therapeutic measures.Item Open Access Antihyperglycemic and antidiabetic effects of Ethyl (S)-2-(1-cyclohexylsulfamide carbamoyloxy) propanoate in streptozotocin-induced diabetic Wistar rats(Université de M'sila, 2016-03) Yassine, Réggami; Hajira, Berredjem; Hadjer, Cheloufi; Malika, Berredjem; Noureddine, BouzernaIn this study, we examined the antihyperglycemic and antidiabetic effects of a novel synthesized molecule, the Ethyl (S)-2-(1-cyclohexylsulfamide carbamoyloxy) propanoate (ESP1b), in streptozotocin (STZ)-induced diabetic Wistar rats. Experimental diabetes mellitus was produced by a single intraperitoneal injection of STZ (55 mg/kg b.w.). Seven day post-injection, animals have received ESP1b orally at the doses of 5, 10 and 20 mg/kg b.w. daily for 28 days. This resulted in a clear decline, in a dose dependent manner, of blood glucose levels during the oral glucose tolerance test (OGTT) and the four weeks of treatment period. ESP1b at 20 mg/kg b.w. has alleviated body weight loss, improved plasma insulin concentration and at the same time markedly decreased the values of glycosylated hemoglobin, lipoproteins and atherogenic ratios. Additionally, ESP1b notably restored renal as well as hepatic functions tests. Histopathological examinations of pancreatic tissue also confirmed the previous biochemical findings. Considering the obtained results, it may be concluded that ESP1b possess a potent antihyperglycemic activity in STZ-diabetic rats possibly related to an insulin-secretagogue effect, which may be responsible for the moderate decrease in blood glucose concentration observed in normal rats administrated with this tested compound.Item Open Access Essential Oil from Aerial Parts of Wild Algerian Rosemary: Screening of Chemical Composition, Antimicrobial and Antioxidant Activities(Université de M'sila, 2019) Noui, HendelEssential oils from the aerial parts of 15 samples of Algerian Rosmarinus officinalis L. were analysed by gas chromatography (GC) and Gas chromatography/mass spectroscopy. Thirty eight components have been characterized; among the monoterpene hydrocarbons α-pinene, camphene and limonene were individuated as the main components; camphor, 1,8-cineole and borneol were the principal oxygenated compounds, caryophyllene, α-bisabolol and partly humulene were the most represented sesquiterpenes. The scavenging activity of the oils was determined by the DPPH model system. The SC50 (Scavenging Concentration) values were in the range 120.4-326.1 μL/mL, representing a moderate antioxidant effectiveness. Essential oils were evaluated for their antimicrobial activity against Escherichia coli and Staphylococcus aureus; as well as against ten fungal strains belonging to Aspergillus, Alternaria, Candida, Fusarium, Penicillium and Saccharomyces genera. The results showed a moderate antimicrobial activity. The Algerian rosemary essential oils could be promising sources of biologically active compounds if they receive further studies on their biological properties.