Abstract:
The work presented here was aimed to investigate the in vivo
anti-inflammatory and in vitro hemostatic activities of Linaria
reflexa extract and to establish the relationship between its bioactivity
and chemical composition. Twenty-three secondary metabolites
were identified, most of them are good anti-inflammatory
agents, in line with data by carrageenin-induced rat paw edema
assays of the n-butanol extract showing high anti-inflammatory
inhibition (63.90%) of edema swelling in the rat paw at the dose
200mg/kg after 4 h. Furthermore, both extent of inflammatory
response and tissue injury were prevented keeping the levels of
rate myeloperoxidase (60.16%) and of malondialdehyde, which is
the final product of lipid peroxidation generated by free radicals
(58.58%). The same extract showed also a remarkable hemostatic
effect established by measuring the coagulation time of decalcified
plasma (45 s), related to its flavonoid glycosides content
